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Endometrial scratch and embryo glue for IVF treatment

Endometrial scratch

Endometrial scratch is a procedure performed on the endometrium prior to implanting embryos to help increase the success rates. It is similar to an endometrial biopsy and the theory behind it is that scratching or injuring the endometrium may trigger a healing response and cause the uterus to be more receptive to embryos. The procedure is controversial because there are a few small research studies that show endometrial scratch may be beneficial in women undergoing intrauterine insemination. Several recent research studies show that there is no significant difference between women who undergo endometrial scratch prior to embryo transfers and those who do not. Due to the limited amount of research available on endometrial scratch; we feel that endometrial scratch does not increase clinical pregnancy rates. However, if a patient desires the procedure to be performed, we can certainly accommodate their request.

 

Embryo glue

Embryo glue is a type of culture media used prior to embryo transfers to help the embryos implant, thus the name “glue”.  Embryos are dipped into bicarbonate buffered culture medium containing hyaluronan and recombinant human albumin. Some research studies have cited that the glue may help implantation rates however many studies have shown that using embryo glue does not seem to increase pregnancy rates; one study showed the pregnancy rates were actually lower. Due to the limited amount of research available on endometrial glue; we feel that it does not increase clinical pregnancy rates. However, if a patient desires the procedure to be performed, we can certainly accommodate their request.

As new research becomes available, we will continue to evaluate these treatment options.